Еffect of reduced nicotinamide adenine dinucleotide on tolerance to physical exercise
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Abstract
Reduced nicotinamide adenine dinucleotide is a key molecule in cellular metabolism, especially in redox reactions. It serves as a carrier of electrons in many biochemical reactions, primarily in anabolic processes, such as the synthesis of fatty acids and nucleotides. Understanding the interplay between NADH metabolism, energy production, and oxidative stress regulation may provide insight into strategies to optimize exercise training and increase exercise endurance in both trained and untrained individuals in everyday life. Therefore, the aim of the research was to study the influence of exogenous NADH on endurance and tolerability of physical activity.
For this, functional, rheographic and statistical research methods were applied.
As a result of taking NADH in tablet form in the main group, after three weeks the value of the PWC170 test increased by 42.5 watts (25.6%) and was significantly higher compared to the control group and before taking the drug (p<0.05) in the main group. In the main group, heart rate after the second exercise was significantly lower at the second examination (p<0.05), and heart rate recovery during the second examination was faster than at the first one. A tendency to decrease and normalization of the slightly elevated initial level of BP was observed after 3 weeks of taking NADH by 7.8%. An increase in the functional capabilities of the cardiovascular system after taking NADH was also noted, which was characterized by an improved course of PsAT recovery at the 2nd and 3rd minutes, especially compared to the fact that during the first examination, the value of PsAT at the 2nd and 3rd minutes of recovery was lower than PsAT0.
It was concluded that taking NADH in tablet form reliably increases the level of physical performance and tolerance to physical exertion even with long-term exposure to stressogenic factors and the absence of physical training, has a positive effect on the state of central hemodynamics, and contributes to the normalization of blood pressure in young people with signs of arterial hypertension. In general, taking exogenous NADH led to an increase in the functional reserves of the cardiovascular system in non-exercising individuals and can be recommended for increasing exercise tolerance in both athletes and non-exercising individuals.
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