Study of the adrenal of rat with kartsynosarkoma Walker W-256

O. B. Shakalo, O. B. Sprin


Introduction. Inadequate lighting in the literature for side effects of anticancer drugs and their harmful effects on the endocrine system, namely, the adrenal glands, dictated the choice of research direction.

Purpose. Find out morpho-functional changes in the adrenal glands of rats wich sick of the Walker carcinosarcoma W-256 under the influence of the influence of cytotoxic drugs.

Methods. The object was white laboratory outbred rats weighing 100-120 g. We used cancersarcoma Woker W–256.

Results.In the article was considered the features of histological changes in glomerular, beam and reticular zones of cortex and medulla of the adrenal glands in rats with transplantation kartsynosarkoma Walker W-256 under the influence of cytostatic preparations. Authors conducted a comparative analysis of the adrenalsstructures in the control animals and rats with transplantation kartsynosarkoma Walker W-256 under the influence of cytostatic preparations.

Originality. For the first time we we proved that the use of the chemical preparations has had a negative impact on the morphofunctional condition of the adrenal glands and cause pathological changes their functional activity.

Conclusion.Our research has shown that the activity of the adrenal glands under the influence of cytostatic preparationsdecreases: the inclusion of lipid in the beam zones cells almost disappear, the zone synthesizes less glucocorticoids, and the brain zone decreases secretion of the adrenaline and the noradrenaline. The greatest changes in the adrenal glands of rats were observed in the beam zone and the least changes were observed in the glomerular. 


adrenals; glomerular; beam and reticular cortex area; cancersarcoma Woker W–256


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