MODULATION OF THE CONTRACTILE ACTIVITY IN THE SMOOTH MUSCLES OF THE COLON BY BIOLOGICALLY ACTIVE SUBSTANCES

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Pavlo Kirichek

Анотація

The large intestine motility ensures of implementation the reservoir function, mixing of chyme, moving it into the rectum and other functions of the gastrointestinal tract. Violation of colon motility leads to pathophysiological manifestations of many diseases and pathologies of the gastrointestinal tract. Very important issue in the modern biology is possibility for correction of the tone and contractile activity in the smooth muscle cells of the large intestine.

Biologically active substances (NH4Cl, calcium channel blocker foridon, potassium channel activator flokalin, compound "C") modulated of the frequency and amplitude of phase components and spontaneous motor activity in smooth muscles with different frequency and intensity. It was established that the level of extracellular and intracellular pH, functioning of calcium and potassium channels of plasmatic membrane play an important role in the dynamics of motor activity of smooth sigmoid myocytes

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Bharucha A. E., Brookes S. J. Neurophysiologic Mechanisms of Human Large Intestinal Motility. Physiology of the Gastrointestinal Tract, Elsevier Inc. 2018, 1812 р. 10.1016/B978-0-12-809954-4.00023-2.

Marklund U. Diversity, development and immunoregulation of enteric neurons. Nat Rev Gastroenterol Hepatol. 2022. No. 2. P. 85-86. doi: 10.1038/s41575-021-00553-y.

Thomasi В., Gulbransen В. Mini-review: Intercellular communication between enteric glia and neurons. Neurosci Lett. 2023. Vol. 29. No. 806. 137263. doi: 10.1016/j.neulet.2023.137263.

Huizinga J. D. Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction. J Smooth Muscle Res. 2019. Vol. 55. No. 0. P. 68-80. doi: 10.1540/jsmr.55.68.

Kim Y. S. Diagnosis and Treatment of Colonic Diverticular Disease. Korean J Gastroenterol. 2022. Vol. 79. No. 6. P. 233-243. doi: 10.4166/kjg.2022.072.

May C. L., Kaestner K. H. Gut endocrine cell development. Mol. Cell. Endocrinol. 2010. Vol. 323. No. 1. P. 70-75.

Lannagan T. R., Jackstadt R., Leedham S. J., Sansom O. J. Advances in colon cancer research: in vitro and animal models. Curr Opin Genet Dev. 2021. Vol. 66. P. 50-56. doi: 10.1016/j.gde.2020.12.003.

Furness J. B., Callaghan B. P., Rivera L. R., Cho H. J. The enteric nervous system and gastrointestinal innervation: integrated local and central control. Adv. Exp. Med. Biol. 2014. No. 817. P. 39-71.

Camilleri М. Diagnosis and Treatment of Irritable Bowel Syndrome: A Review. JAMA. 2021. Vol. 325. No. 9. P. 865 - 877. doi: 10.1001/jama.2020.22532.

Huizinga J. D., Hussain A., Chen J.-H. Interstitial cells of Cajal and human colon motility in health and disease. Am J Physiol Gastrointest Liver Physiol. 2021. Vol. 321. No. 5. G552-G575. doi: 10.1152/ajpgi.00264.2021.

Wang J.-K., Yao S.-K. Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation. Evid Based Complement Alternat Med. 2021. 5560310. doi: 10.1155/2021/5560310.

Wang S.-Z., Yu Y.-J., Khosrow A. Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis. Microorganisms. 2020. Vol. 8. No. 4. Р. 527. doi: 10.3390/microorganisms8040527.

Singh R., Zogg Н., Ghoshal U. C., Ro S. Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders. Front Pharmacol. 2022. Vol. 13. 808195. doi: 10.3389/fphar.2022.808195.

Bassotti G., Satta P. U., Bellini М. Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options. Clin Exp Gastroenterol. 2021. Vol. 14. Р. 413-428.

doi: 10.2147/CEG.S256364.