Changes in the Level of Irisin in the Blood of Women with Obesity Under Different Fitness Programs
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Abstract
The aim of the work was to investigate the possibility of the participation of the myokine irisin in reducing the body weight of obese women in the process of health fitness.
Methods: 87 women of 2 periods of adulthood took part in the study, of which: 73 women with obesity and 14 women with normal body weight. Health fitness programs with mainly aerobic exercises (EG1) and mainly strength exercises (EG2) were implemented three times a week for 3 months using the Zoom online meeting platform. Anthropometric indicators, body composition, biochemical indicators of carbohydrate and fat metabolism were determined in the examined women before and after 3 months of health fitness programs. The concentration of irisin and leptin in blood serum was determined by enzyme-linked immunosorbent assay (ELISA).
Results: under the influence of 3 months of health fitness training with different orientations of classes, probable changes in body composition indicators occurred in the group with mainly strength exercises (body weight decreased by 6.67% (p=0.03), BMI decreased by 6.9% (p=0.025), the percentage of fat mass decreased by 7.82%, visceral fat decreased by 15.45% (p=0.036) compared to the initial values). The levels of irisin and leptin decreased in the women of the two experimental groups. The level of irisin decreased in the first group by 14.7% (0.0156), in the second by 13% (р=0.0039). Changes in the level of leptin were unlikely (in EG1 - by 8.63%, and in EG2 - by 14.32%). Conclusions: the level of irisin in women with obesity probably exceeds the level of women in the control group (p = 0.0223) by 13%; 3-month health fitness programs with different types of physical exercises cause a decrease in the level of irisin and leptin in the blood of obese women; the level of leptin in obese women probably (p < 0.0001) exceeds the level in women with normal body weight and depends on the degree of obesity (p < 0.0001). The higher the BMI, the higher the level of leptin in the blood of obese women.
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