Changes in the Level of Irisin in the Blood of Women with Obesity Under Different Fitness Programs

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Yulia Mykhailivna Panchenko
Svitlana Bohdanivna Drozdovska


The aim of the work was to investigate the possibility of the participation of the myokine irisin in reducing the body weight of obese women in the process of health fitness.
Methods: 87 women of 2 periods of adulthood took part in the study, of which: 73 women with obesity and 14 women with normal body weight. Health fitness programs with mainly aerobic exercises (EG1) and mainly strength exercises (EG2) were implemented three times a week for 3 months using the Zoom online meeting platform. Anthropometric indicators, body composition, biochemical indicators of carbohydrate and fat metabolism were determined in the examined women before and after 3 months of health fitness programs. The concentration of irisin and leptin in blood serum was determined by enzyme-linked immunosorbent assay (ELISA).
Results: under the influence of 3 months of health fitness training with different orientations of classes, probable changes in body composition indicators occurred in the group with mainly strength exercises (body weight decreased by 6.67% (p=0.03), BMI decreased by 6.9% (p=0.025), the percentage of fat mass decreased by 7.82%, visceral fat decreased by 15.45% (p=0.036) compared to the initial values). The levels of irisin and leptin decreased in the women of the two experimental groups. The level of irisin decreased in the first group by 14.7% (0.0156), in the second by 13% (р=0.0039). Changes in the level of leptin were unlikely (in EG1 - by 8.63%, and in EG2 - by 14.32%). Conclusions: the level of irisin in women with obesity probably exceeds the level of women in the control group (p = 0.0223) by 13%; 3-month health fitness programs with different types of physical exercises cause a decrease in the level of irisin and leptin in the blood of obese women; the level of leptin in obese women probably (p < 0.0001) exceeds the level in women with normal body weight and depends on the degree of obesity (p < 0.0001). The higher the BMI, the higher the level of leptin in the blood of obese women.

Article Details

Author Biographies

Yulia Mykhailivna Panchenko, National University of Physical Education and Sports of Ukraine

teacher of the department of medical and biological disciplines
National University of Physical Education and Sports of Ukraine

Svitlana Bohdanivna Drozdovska, National University of Physical Education and Sports of Ukraine

professor of the department of medical and biological disciplines
National University of Physical Education and Sports of Ukraine


Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise / C. Ma et al. Frontiers in Physiology. 2021. Vol. 12. URL: (date of access: 23.11.2023).

Irisin, An Exercise-induced Bioactive Peptide Beneficial for Health Promotion During Aging Process / H. Zhang et al. Ageing Research Reviews. 2022. P. 101680. URL: (date of access: 23.11.2023).

Exercise hormone irisin is a critical regulator of cognitive function / M. R. Islam et al. Nature Metabolism. 2021. Vol. 3, no. 8. P. 1058–1070. URL: (date of access: 23.11.2023).

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging / Y. Chen et al. Experimental Biology and Medicine. 2021. Vol. 246, no. 14. P. 1597–1606. URL: (date of access: 23.11.2023).

Molecular Basis of Irisin Regulating the Effects of Exercise on Insulin Resistance / J. Lin et al. Applied Sciences. 2022. Vol. 12, no. 12. P. 5837. URL: (date of access: 23.11.2023).

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes / Y. Zhang et al. American Journal of Physiology-Endocrinology and Metabolism. 2016. Vol. 311, no. 2. P. E530–E541. URL: (date of access: 23.11.2023).

The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats / S. Ozcan et al. Archives of Physiology and Biochemistry. 2020. P. 1–8. URL: (date of access: 23.11.2023).

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise / J. Brenmoehl et al. International Journal of Biological Sciences. 2014. Vol. 10, no. 3. P. 338–349. URL: (date of access: 23.11.2023).

Irisin and exercise training in humans – Results from a randomized controlled training trial / A. Hecksteden et al. BMC Medicine. 2013. Vol. 11, no. 1. URL: (date of access: 23.11.2023).

The Effect of Exercise Training on Irisin Secretion in Patients with Type 2 Diabetes: A Systematic Review / M. Vecchiato et al. Journal of Clinical Medicine. 2022. Vol. 12, no. 1. P. 62. URL: (date of access: 23.11.2023).

Relationship between circulating irisin levels and overweight/obesity: A meta-analysis / J. Jia et al. World Journal of Clinical Cases. 2019. Vol. 7, no. 12. P. 1444–1455. URL: (date of access: 24.11.2023).

Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females / N. C. Winn et al. PLOS ONE. 2017. Vol. 12, no. 1. P. e0170690. URL: (date of access: 24.11.2023).

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity / H. Staiger et al. PLoS ONE. 2013. Vol. 8, no. 4. P. e61903. URL: (date of access: 24.11.2023).

The combined effect of dietary supplement “Leptin Manager” and power fitness exercises on weight loss in women with different LEPR (rs1137101) genotypes / S. Drozdovska et al. Sporto mokslas / Sport Science. 2018. Vol. 2, no. 92. P. 48–54. URL: (date of access: 24.11.2023).

Moienneia N., Attarzadeh Hosseini S. R. Acute and chronic responses of metabolic myokine to different intensities of exercise in sedentary young women. Obesity Medicine. 2016. Vol. 1. P. 15–20. URL: (date of access: 24.11.2023).

Fitness and strength responses to distinct exercise modes in twins: Studies of Twin Responses to Understand Exercise as a THerapy (STRUETH) study / C. E. Marsh et al. The Journal of Physiology. 2020. Vol. 598, no. 18. P. 3845–3858. URL: (date of access: 24.11.2023).

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / P. Boström та ін. Nature. 2012. Т. 481, № 7382. С. 463–468. URL: (дата звернення: 24.11.2023).