Regulation of tissue blood flow by the action of hydrogen sulfide in liver rats

L. O. Slobodianyk, P. I. Yanchuk

Abstract


The tissue blood flow in the liver, systemic blood pressure, pressure in the portal vein was investigated in acute experiments on rats. It was shown that the injection of L- cysteine increases tissue blood flow and decreases pressure in the vessels of liver. After injection blocker DL-proparhilhlitsyn in the portal vein synthesis of endogenous hydrogen sulfide reduced. The effects of L-cysteine causing constriction of intrahepatic vessels. Вlood pressure in the portal vein and carotid artery increasing, tissue blood flow reduced in the liver rats

Keywords


liver; L- cysteine; DL - propargilglitsin; local blood flow

References


Смаглий Л.В. Роль Na+,K+,2Cl−-котранспорта в механизмах вазоконстрикторного действия сероводорода / Смаглий Л.В. // Современные проблемы науки и образования – 2013. – N2. – C. 543-549

Янчук П.І. Модификационный електрод для регистрации локального кровотока в слизистой оболочке желудка методом водородного клиренса / Янчук П.І., Палатный Т.П., Русинчук Я.И. // Рос.Физиол.Журн. – 2005. – Т.91, N 9. – С.1108-1110

Chen A.F., Chen D.D., Daiber A., at all. Free radical biology of the cardiovascular system / Chen A.F., Chen D.D., Daiber A., at all. // Clin. Sci. (Lond) – 2012. – V 123. –P.73-91

Hernandez Guerra M. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension / Hernandez Guerra M., Garcia Pagan J.C., Turnes J. // Hepatology. – 2006 – V 43 – P. 485 – 491

Jain S.K. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? / Jain S.K., Bull R., Rains J.L., Bass P.F. // Antioxid. Redox Signal. – 2010. – V 12. – Р.1333-1337

Kimura H. Hydrogen sulfide: its production and functions / Kimura H // Exp. Physiol. – 2011. – V 96. – P.833-835.

King S.B. Potential biological chemistry of hydroge sulfide (H2S) with the nitrogen oxides / King S.B. // Free Radic. Biol. Med. – 2013. – V 55. – P.1-7

Lim J. J. Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells / Lim J. J., Liu Y.H., Win E. S., Khin J. // Am. J. Physiol. Cell. Physiol. – 2008. – V 295. – P. 1261-1270

Lowicka E. Hydrogen sulfide (H2S) – the third gas of interest for pharmacologists / Lowicka E. // Pharmacological Reports.- 2007.- V 59. – P.4-24

Magableh M.R. Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta / Magableh M.R., Hart J.L. // Naunyn. Schmiedebergs Arch. Pharmacol. –2011. – V 383. – P.403-413

Morel A. Antioxidative properties of hydrogen sulfide may involve in its antiadhesive action on blood platelets / Morel A., Malinowska J., Olas B. // Clin. Biochem. – 2012. – V 45. – P.1678-1682

Olson K.R. Is hydrogen sulfide a circulating “gasotransmitter” in vertebrate blood? / Olson K.R. // Biochim. Biophys, Acta. – 2009. – V 1787. – Р.856-863

Renga B. Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-beta- synthase (CBS) and cystathionine-gamma-lyase (CSE) / Renga B. // Inflamm. Allergy Drug Targets – 2011. – V 10. – P.85-91

Rossoni G. The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart / Rossoni G., Sparatore A., Tazzari V. // Br. J. Pharmacol. – 2008.– V 153. – P.100-109

Streeter E. An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries / Streeter E., Hart J., Badoer E. // Naunyn Schmiedebergs Arch. Pharmacol. – 2012. – V 385. – P.991-1002

Sun Yan Hydrogen sulfide and vascular relaxation / Sun Yan, Tang Chao-shu, Du Jun-bao and JIN Hong-fang // Chin. Med. J. – 2011 – V 124(22). – P.3816-3819

W. Zhao The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener / W. Zhao, J. Zhang, Y. Lu // EMBO J. – 2001 – Vol.20(21). – P. 6008-6016.

Xiao Yu Tiana NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+channel / Xiao Yu Tiana,WingTak Wonga, Nazish Sayed // Pharmacological Research – 2012 – V 65. – P.239-246

Yang G. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase / Yang G., Wu L., Jiang B., Yang W, Qi J., Cao K., Meng Q., Mustafa A.K., Mu W., Zhang S // Science – 2008. – V 322. – P.587-590

Yang G. Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in alpha5beta1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells / Yang G., Li H., Tang G., Wu L., Zhao K., Cao Q., Xu C., Wang R. // J. Mol. Cell Cardiol. – 2012. – V 52. – Р.677-688.


Full Text: PDF (Українська)

Refbacks

  • There are currently no refbacks.
Archive
2014 2 36
2015 2 19
2016 1 2
2017 1 2
2018 1 2
2019 1  

User

Information

Journal Content

Browse

Language