Features of interregional interaction in the brain of military men with traumatic brain injuries during testing visual working memory on complex stimuli
Introduction. Traumatic brain injuries (TBI) cause a variety of cognitive impairments, which consist in degradation of memory, attention, problems with the perception and understanding of information, a decrease in control and the adoption of impulsive decisions, and much more. A key motivation for exploring the capacity of visual working memory (VWM) is that it is a predictor of intelligence and correlates with the ability to suppress unwanted, obsessive thoughts and recollections.
Purpose. The purpose of the work was to determine the effectiveness of visual working memory on complex stimuli (VWMc) and to determine the neural networks and the corresponding brain structures that are involved during the testing of the VWMc in the brain of the military men of the Armed Forces of Ukraine, who took part in the operations in the east of Ukraine and have TBI, later – military men with TBI.
Methods. This study involved 16 male volunteers, right-handed, aged 18-21, without complaints of health - students of Taras Shevchenko National University of Kyiv (control group) and 17 male volunteers, right-handed, aged 27-43, military men with TBI - patients of the Institute for Occupational Health of the NAMS of Ukraine, SI, Kyiv. EEG studies, coherent analysis and analysis of brain dipoles of brain activity using the Loreta program during testing of VWMc.
Results. When testing VWMc in a group of military men with TBI and the accuracy and time of reaction were significantly worse compared with the control group: 0.44 [0.32; 0.48] relative error vs. 0.28 [0.23; 0.36] relative error *; reaction time 1326 [1056; 1588] ms vs. 921 [767; 999] ms **.
Conclusion. It was showed that mnemonic and executive functions in the control group at increase cognitive load were dependent on a common front-parietal neural network in which integration, coordination, prognostications and control of the relevant processes were carried out (strategic decision-making system), while the military men with TBI discovered an occipital-parietal system for storing information based on distinguished features and imaginary planning of motor answer (associative decision-making system).
Wongupparaj, P., Kumari, V., &Morris, R.G. (2015).The relation between a multicomponent working memory and intelligence: The roles of central executive and short-term storage functions. Intelligence,53, 166-180.doi: 10.1016/j.intell.2015.10.007
Brewin, C. R., &Beaton, A. (2002). Thought suppression, intelligence, and working memory capacity. Behav Res Ther, 40(8), 923-930.doi:10.1016/S0005-7967(01)00127-9
Lauer, J., Moreno-Lуpez, L., Manktelow, A., Carroll E. L, Outtrim, J.G., Coles, J.P., …Stamatakis, E. A. (2017). Neural correlates of visual memory in patients with diffuse axonalinjury. Brain Inj,31(11), 1513-1520.doi:10.1080/02699052.2017.1341998
Shum, D. H., Harris, D.,&O'Gorman, J. G. (2000). Effects of severe traumatic brain injury on visual memory. J Clin Exp Neuropsychol,22(1), 25-39.doi: 10.1076/1380-3395(200002)22:1;1-8;FT025
Knyr, O., Filimonova, N., Makarchuk, M., Zyma, I., Kalnysh, V., &Cheburkova, A.(2018). Interregional brain interaction in visual working memory of military men with traumatic brain injuries. Naukovyi visnyk Skhidnoievropeiskoho natsionalnohou niversytetu imeni Lesi Ukrainky. Seriia: Biolohichni nauky (National East European LesiaUkrainka University scientific bulletin. Serie: Biological sciences) 2018. № 8(381). C.75-85.(In Ukr)
Maia, P. D, &Kutz, J. N. (2017). Reaction time impairments in decision-making networks as a diagnostic marker for traumatic brain injuries and neurodegenerative diseases. Comput Neurosci, 42(3), 323-347.doi: 10.1007/s10827-017-0643-y
Kulaychev, A. P. (2009). About the informativeness of coherentanalysis. Zhurnal vyisshey nervnoy deyatelnosti (Journal of higher nervous activity),59, 766-775. (In Rus)
Domenech, P.,&Koechlin, E. (2015). Executive control and decision-makingin the prefrontal cortex. Curr Opin Behav Sci, 1, 101-106.doi: 10.1016/j.cobeha.2014.10.007
Hampshire, A., Chamberlain, S. R, Monti, M. M., Duncan, J., &Owen, A. M. (2010). The role of the right inferior frontal gyrus: inhibition and attentional control. Neuroimage,50(3), 1313-1319.doi: 10.1016/j.neuroimage.2009.12.109
Christophel, T. B., Klink, P. C., Spitzer, B., Roelfsema, P. R., &Haynes, J. D. (2017). The distributed nature of working memory. Trends Cogn Sci, 21(2), 111-124. doi: 10.1016/j.tics.2016.12.007
Daume, J., Gruber, T., Engel, A. K., &Friese, U. (2017). Phase-amplitude coupling and long-range phase synchronization reveal frontotemporal interactions during visual working memory. J Neurosci, 37(2), 313-322.doi: 10.1523/JNEUROSCI.2130-16.2016
Ranganath, C., &D'Esposito, M. (2005). Directing the mind's eye: prefrontal, inferior and medial temporal mechanisms for visual working memory. Curr Opin Neurobiol,15(2), 175-182.doi: 10.1016/j.conb.2005.03.017
Knyr, O., Filimonova, N., Makarchuk, M., Cheburkova, A., Zyma, I., &Kalnysh, V. (2018). Features of interregional interaction in the brain of military men with traumatic brain injuries during the testing of simple sensory-motor reaction.Visnyk Kyivskoho natsionalnohou niversytetu imeni Tarasa Shevchenka: Biolohiia (Taras Shevchenko National University of Kyiv bulletin: Biology),75, 50-54. (In Ukr)
Vozniuk,V., Filimonova, N., Makarchuk, M., Zyma, I., Horbunov, O., Kalnysh, V. (2018) Features of heart rate regulation and activity of the brain during testing the reaction of choise in the military man with traumatic brain injury. Visnyk Kyivskoho natsionalnohou niversytetu imeni Tarasa Shevchenka: Problemi reguliacii fiziologichnich funkcij (Taras Shevchenko National University of Kyiv bulletin: Problems of physiologic functions regulation), 25, 26-31..(In Ukr)
Slotnick, S. D., &Schacter, D. L. (2006). The nature of memory related activity in early visual areas .Neuropsychologia, 44(14), 2874-2886.doi: 10.1016/j.neuropsychologia.2006.06.021
Gerlacha, C., Aasidea, C. T., Humphreysc, G. W., Gade, A., Paulson, O. B., &Law, I. (2002). Brain activity related to integrative processes in visual object recognition: bottom-up integration and the modulatory inﬂuence of stored knowledge. Neuropsychologia, 40(8), 1254-1267.doi:10.1016/S0028-3932(01)00222-6
Albers, A. M., Kok, P., Toni, I., Dijkerman, H. C., &deLange, F. P. (2013) Shared representations for working memory and mental imagery in early visual cortex. Curr Biol,23(15), 1427-1431. doi:10.1016/j.cub.2013.05.065
Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., …Pine, D. S. (2004). Choice selection and reward anticipation: an fMRI study. Neuropsychologia, 42(12), 1585-1597. doi:10.1016/j.neuropsychologia.2004.05.011
Prabhakaran, V., Narayanan, K., Zhao, Z., &Gabrieli, J. D.(2000).Integration of diverse in formation in working memory within the frontal lobe. NatNeurosci,3(1), 85-90. doi:10.1038/71156
Tovar-Moll, F., Monteiro, M., Andrade, J., Bramati, I. E., Vianna-Barbosa, R., Marins, T., ...Lent, R.(2014). Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proceedings of the National Academy of Sciences, 111(21), 7843-7848. doi:10.1073/pnas.1400806111
- There are currently no refbacks.