Change of reactivity of the respiratory system under the influence of fatigue in the process of prolonged stressful physical activity

V. S. Mishchenko, O. M. Lysenko


Introduction. A change in the complexity of respiratory reactivity in the process of intense athletic training is a reflection of the integration of external and internal factors, one of the important mechanisms for optimizing the respiratory response.

Purpose. In order to deepen understanding of the role of regulatory factors in increasing the limits of efficiency, it became necessary to analyze changes in the reactivity of the respiratory system in the process of tense muscle load, performed "up to failure".

Methods. When performing a long (about 1 hour) load "to failure" with a relative intensity of 65% of VO2max, the dynamics of VE, Q and gas exchange, as well as changes in the level and speed of the respiratory response to short-term effects during the performance of long physical work were investigated: 1) step increase the work capacity by 17% from the 40th minute of work, by 33% from the 50th minute of work; 2) temporary (within 30 s) rectangular increase of work capacity by 33% after every 5 minutes of physical work; 3) periodically repeated short-term hypoxic and hypercapnic stimuli using the "reverse" breathing method.

Results. Despite the individual peculiarities of changing the sensitivity of the ventilatory reaction to CO2 during prolonged loading, the obtained data indicate a relative decrease in the acidophilic respiration stimulus at the end of the load on the background of fatigue. There is reason to believe that the modification of the reactivity of the respiratory system to the load, including the CO2-H+-stimulus, largely determined the changes associated with the development of fatigue. During a long load of submaximal intensity of continuous or repeated type of fan reaction and its stimuli in a certain way turned. At the end of such a load on the background of fatigue development there was a relative decrease in ventilation of the lungs and such changes in the gas composition of blood, its acid-base state, which are characteristic of relative hypoventilation of the lungs

Conclusion. When performing intense physical activity, the main changes in the development of fatigue are the decrease in the peak values of the reaction, as well as the speed of their deployment. It is possible to think that in this regard the nature of the training effects in the initial part of the training session and at the end of it differed. In this case, the highest effect of specially directed means of training of this kind persisted as long as maintaining high levels (peaks) and the rate of deployment of the fan reaction, as well as reactions on VO2 and VСО2. All this points to the need to take into account the nature of such changes in the reactivity of the respiratory system during the training session and the use of special means for its correction.


sport; reactivity; cardiorespiratory system; physical activity; hypercapia; hypoxia


Mishchenko, V. S., Lysenko, O. М., Siversky, D. Ye. (1994). Changes in the sensitivity of the human respiratory system to hypercapnic and hypoxic stimuli when exposed to physical exertion of varying intensity. Fiziologicheskiy zhurnal im. I. M. Sechenova (Physiological Journal named after IM Sechenov), 7, 23-28 (in Rus.).

Balykin, M. V., Pupyreva, E. D., Balykin, Yu. M. (2011). The influence of hypoxic training on physical performance and functional reserves of the body of athletes. Vestnik Tverskogo gosudarstvennogo universiteta. Seriya: Biologiya i ekologiya (Bulletin of Tver State University. Series: Biology and Ecology), 21, 7-16. (in Rus.).

Borisenko, N. S., Golovina, A. S., Golubev, V. N. (2010). Reactions of the human respiratory system to normobaric hypoxic hypoxia. Vestnik Rossiyskoy voenno-meditsinskoy akademii (Bulletin of the Russian Military Medical Academy), 1, 117-123. (in Rus.).

Vodyanitsky, S. N., Divert, V. E., Krivoshchekov, S. G. (2011). External respiration and gas exchange with intermittent normobaric hypoxia in athletes with different types of training process. Byulleten sibirskogo otdeleniya Roissiyskoy akademii meditsinskih nauk (Bulletin of the Siberian Branch of the Roysiyskoy Academy of Medical Sciences), 31 (3), 33-39. (in Rus.).

Zabolotskikh, N. V. (2005). Peripheral and systemic hemodynamic changes in response to transient hypercapnia and hypoxia in healthy people. Uspehi sovremennogo estestvoznaniya (Successes of modern science), 2, 77-78. (in Rus.).

Krivoshchekov, S. G., Divert, G. M., Divert, V. E. (2005). Expansion of the functional range of reactions of respiration and gas exchange with repeated hypoxic effects. Fiziologiya cheloveka (Human physiology), 31 (2), 132-141. (in Rus.).

Pupyreva, E. D., Balykin, M. V., Makaeva, R. Sh. (2009). Influence of normobaric hypoxia on the aerobic performance of athletes. Vestnik novyih meditsinskih tehnologiy (Bulletin of new medical technologies), 16 (2), 214-215. (in Rus.)

Prieur, F., Benoit, H., Busso, T. (2005). Effect of endurance training on the VO2-work rate relationship in normoxia and hypoxia. (Med. Sci. Sports Exerc), 37, 664-669.

Yamborko, P. V. (2004). The use of normobaric hypoxia, hypercapnia and resistive resistance to respiration to expand the functional reserves of the body. Fundamentalnyie issledovaniya (Basic research), 5, 139-140. (in Rus.)

Friedmsnn, B., Frese, F., Menold, E., Bartsch, P. (2007). Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners. (European Journal of Applied Physiology), 101 (1), 67-72.

Hawley, J. A., Noakes, T. D. (1992). Peak power output predicts maximal oxygen uptake and performance time in trained cyclists. (European Journal of Applied Physiology), 65, 79-83.

Blain, G., Meste, O., Bouchard, T., Bermon, S. (2005). Assessment of ventilatory thresholds during graded and maximal exercise test using time varying analysis of respiratory sinus arrhythmia. Br. J. Sports. Med., 39 (7), 448-452.

Buchheit, M., Gindre, С. (2006). Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load. Am. J. Physiol. Heart. Circ. Physiol., 291, 451-459.

Ferreira-Junior, A. J., Zanetti, G. G., Couto, P. G. (2012). Transition Points of Heart Rate during a Progressive Maximal Intermittent Field Test in Young Soccer Players. Journal of Exercise Physiology online, 15 (3), 81-88.

Roper, J. A., Stegemöller, E. L., Tillman, M. D., Hass,C. J. (2012) Oxygen consumption, oxygen cost, heart rate, and perceived effort during split-belt treadmill walking in young healthy adults.European Journal of Applied Physiology, August.

Cherkes, L. I., Ilyin, V. N. (2012). Factors determining the functional state of the body’s regulatory systems in athletes after staying in the midlands. Fiziologichny`j zhurnal (Physical journal), 58 (3), 30 - 34. (in Rus.)

Chapman, R. F., Emery, M., Stager, J. M. (1998). Extent of expiratory flow limitation influences the increase in maximal exercise ventilation in hypoxia. Respiration Physiology, 113 (1), 65–74.

Wilhite, D. P., Mickleborough, T. D., Laymon, A. S., Chapman, R. F. (2013). Increases in VO2max with “live high–train low” altitude training: role of ventilatory acclimatization. European Journal of Applied Physiology, 113 (2), 419-426.

Lysenko, Olena (2007). Cardiorespiratory responseveness and manifestations of energy potential for elite athletes. Research Yearbook. Studies in Physical Education and Sport, 13 (2), 235-238.

Lysenko, O. M. (2008). The manifestation of the stability of the reactions of the cardiorespiratory system in qualified athletes in conditions of achieving the maximum level of consumption of O2. Sportivnaya meditsina (Sport Medicine), 1, 42-47. (in Rus.)

Bearden, S. E., Henning, Р. С., Bearden, T. A., Moffatt, R. J. (2004). The slow component of VO2 kinetics in very heavy and fatiguing square-wave exercise. European Journal of Applied Physiology. Publisher: Springer-Verlag Heidelberg, 91 (5-6), 586 – 594.

Cunha, F. A., Midgley, A. W., Monteiro, W. (2012). How long does it take to achieve steady state for an accurate assessment of resting VO2 in healthy men? European Journal of Applied Physiology, 12

Grassi, B., Porcelli, S., Salvadego, D., Zoladz, J. A. (2011). Slow VO2 kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance. European Journal of Applied Physiology, 111 (3), 345-355.

Katayama, K., Sato, K., Matsuo, H. (2004). Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes. European Journal of Applied Physiology, 92, 75-83.

Smekal, G., Duvillard, S. P.von, Pokan, R. (2012). Blood lactate concentration at the maximal lactate steady state is not dependent on endurance capacity in healthy recreationally trained individuals. European Journal of Applied Physiology, 112 (8), 3079-3086.

Shinkaruk, O. A., Lysenko, O. M., Gunina, L. M. (2009). Medico-biological support for the training of athletes of national teams of Ukraine from Olympic sports. Per community Ed. O.A. Shinkaruk – K.: Olympic literature, 2009. – 144 p. (in Ukr.)

Tomiak, Tomasz, Lysenko, Оlena, Zasada, Mariusz (2005). Fast Kinetics and Sensitivity of Cardiorespiratory Responses in Athletes of Different Sport Events. Research Yearbook. Studies in Physical Education and Sport, 11, 25-29.

Aghajanyan, N.A., Dvoenosov,V.G. (2010). Features of adaptive reactions of the cardiorespiratory system in individuals with different levels of pulmonary ventilation with a combined effect of hypoxia and hypercapnia. Vestnik Uralskoy meditsinskoy akademicheskoy nauki (Bulletin of the Ural Medical Academic Science), 32 (4), 17-21. (in Rus.)

Vinogradov, V.E., Lysenko, О.М. (2005). Changes in the physiological reactivity of the cardiorespiratory system to respiratory homeostasis shifts with the use of a complex of means of preliminary stimulation of working capacity. Sportivnaya meditsina (Sport Medicine), 1, 35-41. (in Rus.)

Lysenko, О., Vinogradov, V., Sologub, L. (2011). The use of mobilization-type extra-training means to increase the special performance of high-class athletes in a competition. Fizicheskoe vospitanie studentov tvorcheskih spetsialnostey (Physical education of students of creative specialties), 6, 3-11. (in Rus.)

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