Influence of hyperventilation on the dynamic of Carbon (IV) Oxide in alveolar air

V. A. Zavhorodnia, S. O. Kovalenko, L. I. Kudiy


Introduction. Hyperventilation occurs under the influence of environmental factors, neuro-psychic stress, in sports activities, with the introduction of pharmacological substances, accompanies a number of diseases. However, there are insufficient studies of the individual peculiarities of СО2 change dynamics in the alveolar air at hyperventilation test and after it.

Purpose. To analyze the dynamics of changes in the level of carbon (IV) oxide in the alveolar air while testing the regulated respiration with a frequency of 30 cycles per minute in healthy young men.

Methods. Measurements were performed on 81 healthy young men aged 18-22. The level of СО2 in the exhaled air was determined in the lateral flow by the infrared spectrometry method on the capnograph Datex Normocap (Finland). The stress of СО2 in the alveolar air was estimated according to its level at the end of the exhalation (PetCO2).

Results. At the respiration with a frequency of 30 cycles per minute1 for 10 minutes, the level of PetCO2 decreases from 40.12 ± 0.361 mm Hg to 18.59 ± 0.542 mm Hg.  In the 40-minute recovery period after the test, the return of PetCO2 to the initial level does not occur. There are significant individual peculiarities of PetCO2 reactivity to hyperventilation and recovery after it.

Originality. It has been shown that the stress reactivity of carbon (IV) oxide in the alveolar air to a sample with respiration of 30 cycles per minute and after recovery after it depends on its initial level – the lower the level of Pet CO2, the lower the reactivity and the faster recovery. The stress reactivity of carbon (IV) oxide in the alveolar air to testing respiration of 30 cycles per minute and to the recovery during the first 5-10 minutes after it depends on the initial respiration rate.

Conclusion. When evaluating a hyperventilation test, the initial level of СО2 in the alveolar air and respiratory rate should be taken into account.


carbon (IV) oxide; hyperventilation; hypocapnia


Agadzhanyan N.A., Chizhov A.Ya. (2003). Classification of hypoxic, hypo- and hypercapnic states. Fiziologhichnyj zhurnal [Journal of Physiology]. 49, 3. 11-16. (in Russ.)

Panina M.I. (2003). Pathophysiological aspects of hyperventilation and hyperventilation syndrome. Kazanskyj medycynskyj zhurnal [Kazan Medical Journal]. 84, 4. 288-293. (in Russ.)

Shea S.A. (1996). Behavioural and arousal-related influences on breathing in humans. Еxperimental physiology. 81(1). 1-26.

Coverdale N.S., Gati J.S., Opalevych O., Perrotta A., Shoemaker J.K. (2014). Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia. J Appl Physiol (1985). Nov 15; 117(10). 1090-1096. doi: 10.1152/japplphysiol.00285.2014.

Shurygin, I. A. (2000). Breathing monitoring: pulse oximetry, capnography, oximetry. SPb.: "Nevsky Dialect"; M.: "Publishing BINOM". (in Russ.)

Kim K.W., Choi H.R., Bang S.R., Lee J.W. (2016). Comparison of end-tidal CO2 measured by transportable capnometer (EMMA™ capnograph) and arterial pCO2 in general anesthesia. J Clin Monit Comput. 30(5). 737-741. doi:10.1007/s10877-015-9748-x.

Kulykov V.P., Kuznecova D.V. (2013). The reaction of cerebral blood flow and systemic blood pressure to hypercapnia and hypocapnia in humans. Рatolohichna fiziolohiia ta eksperymentalna terapiia [Pathological physiology and experimental therapy]. 57, 1. 41-44. (in Russ.)

Dyomin D. B., Posototinova L.V. (2017). The significance of the level of hypocapnia in changing the electroencephalogram with prolonged hyperventilation in humans. Zhurnal medyko-byolohycheskykh yssledovanyi [Journal of medical and biological research]. 3. 24-32. DOI: 10.17238 / issn2542-1298.2017.5.3.24 (in Russ.)

Burich E.A. (2007). Interrelation of hypocapnia, hypoxia, cerebral blood flow and electrical activity of the brain with arbitrary hyperventilation in humans. Rossyiskyi fyzyolohycheskyi zhurnal ymeny Y.M. Sechenova [Russian physiological journal named after I.M. Sechenov]. 9. 982-1000. (in Russ.)

Kovalenko S.O., Kudiy L.I., Kalenychenko O.V. (2004). Heart rhythm variability in individuals with different respiration frequency. Fiziolohichnyi zhurnal. 50, 6. 43-47. (in Ukr.)

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