Features of the qualitative composition of the bile of rats at different times during the experimental chronic necrotizing pancreatitis

Z. A. Gorenko, O. A. Grinchenko, S. P. Veselsky

Abstract


Chronic pancreatitis is an inflammatory disease of the pancreas, characterized by progressive changes in the morphological structure, as well as endocrine and exocrine insufficiency. The aim was to investigate the features of the quality of the bile of rats at L-arginine experimental chronic necrotizing pancreatitis. Bile secretion liver function was studied in acute experiments on 13th and 68th days after the last administration of L-arginine. It was established that the nature of the secretory response of the liver depends on the duration of the pathology progress. On the 13th day, the volume of selected bile increased, but the concentration of bile acids, phospholipids and free cholesterol reduced. Instead, the concentration of cholesterol esters and triglycerides increased. Such changes may indicate an imbalance basic micelle-forming components of bile in the early development or exacerbation of chronic pancreatitis. Two months course of pathology observed recovery of cholepoiesis to control values, but solubilizing properties of bile deteriorating – the concentration of bile acids, phospholipids and free cholesterol significantly reduced, resulting decrease in the potential capacity to cholesterol crystallization. Also on the 68th day in the bile of rats significantly increased the concentration of cholesterol esters, triglycerides and free fatty acids, which is one indicator of the severity of chronic pancreatitis.


Keywords


chronic pancreatitis; bile secretion; bile acids; cholesterol; cholesterol esters; triglycerides; free fatty acids

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